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Transition Metal-Catalyzed Couplings

transition metal-catalyzed coupling reactions  


Named Reactions in Organic Synthesis


Featured reactions:

 

Transition-metal-catalyzed cross-coupling reactions have gained widespread use in both academic and industrial synthetic chemistry laboratories as a powerful methodology for the formation of C-C and C-Heteroatom bonds and has subsequently become an indispensable tool in modern organic synthesis.

Reactions using transition metal catalysts have a rich history that led to the awarding of the 2010 Nobel Prize in Chemistry to Professors Suzuki, Heck, and Negishi for their pioneering contributions in this field.

One of the earliest named reactions in this category was discovered in 1901 by F. Ullmann when he combined two equivalents of an aryl halide with one of powdered copper at a high temperature and generated the equivalent biaryl compound. Subsequently the Ullmann reaction has become a convenient method to create numerous biaryl compounds.

Featured in this series are the following named reactions:


Among the other important named reactions that make use of this technique are:-

  • Buchwald-Hartwig coupling
  • Castro-Stevens coupling
  • Glaser coupling
  • Kumada cross-coupling
  • Larock indole synthesis
  • Miyaura boration
  • Sonagashira cross-coupling


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Other reaction categories:

Radical reactions NEW!

Electrophilic aromatic substitution

Nucleophilic substitution reactions

Heterocycle formation

Oxidation

Reactions involving carbonyl compounds

Reduction reactions

Rearrangement reactions

Electrophilic addition reactions


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