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107-19-7 - Propargyl alcohol, 99% - 2-Propyn-1-ol - A10295 - Alfa Aesar

A10295 Propargyl alcohol, 99%

Número CAS
107-19-7
Nombre Alternativo
2-Propyn-1-ol

Tamaño Precio ($) Cantidad Disponibilidad
100ml 11,97
500ml 32,96
2500ml 108,94
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Propargyl alcohol, 99%

MDL
MFCD00002912
EINECS
203-471-2

Propiedades químicas

Fórmula
C3H4O
Peso molecular
56.06
Punto de fusión
-53°
Punto de ebullición
114-115°
Punto de inflamabilidad
33°(91°F)
Densidad
0.949
Índice de refracción
1.4320
Solubilidad
Fully miscible in water.

Aplicaciones

Propargyl alcohol is a solvent stabilizer that is useful as an intermediate in organic synthesis, an electroplating brightener additive. It is useful 3-carbon fragment in acetylene coupling reactions, It undergoes Pd-catalyzed O-coupling with alcohols to give the corresponding 1-methoxyallyl ethers.

Notas

Store at 4°C. Incompatible with oxidizing agent, strong acids, strong bases, amines, phosphorous pentoxide, isocyanate vapor & heat.

Referencias documentales

Yuji Kozawa; Miwako Mori. Synthesis of different ring-size heterocycles from the same propargyl alcohol derivative by ligand effect on Pd(0). Tetrahedron Letters. 2002, 43 1499-1502.

Useful 3-carbon fragment in acetylene coupling reactions. The hydroxyl group can be protected as its THP ether; see, e.g.: Org. Synth., 76, 178 (1998), or 1-ethoxyethyl ether (see Ethyl­ vinyl­ ether, A15691): Org. Synth., 76, 199 (1998). C-Alkylation can also be accomplished without O-protection by using 2 equivalents of base (LiNH2); see, e.g., J. Chem. Soc., Perkin 1, 85 (1988); Org. Synth. Coll., 8, 415 (1993).

O-methylation, followed by treatment with t-BuOK affords methoxyallene, a valuable reactive intermediate. It undergoes Pd-catalyzed O-coupling with alcohols to give the corresponding 1-methoxyallyl ethers: Synlett, 192 (1998). Lithiation leads to 1-lithio-1-methoxyallene: J. Org. Chem., 50, 5308 (1985); 58, 6377 (1993). For a brief feature on methoxyallene with further examples, see: Synlett, 1697 (2000).

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H301-H311-H331-H314-H226-H411

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage. Flammable liquid and vapour. Toxic to aquatic life with long lasting effects.

Indicaciones de precaución: P210-P260-P261-P301+P310-P303+P361+P353-P305+P351+P338-P361-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,7809
Beilstein
506003
Clase de peligro
6.1
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2905.29
TSCA
Yes
RTECS
UK5075000

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