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6066-82-6 - N-Hydroxysuccinimide, 98+% - HOSu - 1-Hydroxy-2,5-pyrrolidinedione - A10312 - Alfa Aesar

A10312 N-Hydroxysuccinimide, 98+%

Número CAS
6066-82-6
Nombre Alternativo
HOSu
1-Hydroxy-2,5-pyrrolidinedione

Tamaño Precio ($) Cantidad Disponibilidad
25g 29,91
100g 84,60
500g 322,20
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

N-Hydroxysuccinimide, 98+%

MDL
MFCD00005516
EINECS
228-001-3

Propiedades químicas

Fórmula
C4H5NO3
Peso molecular
115.09
Punto de fusión
94-99°
Sensibilidad
Hygroscopic
Solubilidad
Soluble in water, dimethyl formamide, alcohols and ethyl acetate. Insoluble in cold ether.

Aplicaciones

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

Notas

Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides and strong bases. Store in a cool place.

Referencias documentales

Reagent for the preparation of active N-hydroxysuccinimide esters for peptide coupling with minimum racemization: J. Am. Chem. Soc., 86, 1839 (1964), or as an additive in the DCC method (see N,N'-Dicyclohexyl­carbodiimide, A10973 ) to suppress racemization: J. Am. Chem. Soc., 89, 7151 (1967). For peptide reagents, see Appendix 6.

For a study of the aminolysis of N-hydroxysuccinimide esters, see: J. Org. Chem., 53, 3583 (1988).

Park, C.; Vo, C. L. N.; Kang, T.; Oh, E.; Lee, B. J. New method and characterization of self-assembled gelatin-oleic nanoparticles using a desolvation method via carbodiimide/N-hydroxysuccinimide (EDC/NHS) reaction. Eur. J. Pharm. Biopharm. 2015, 89, 365-373.

Peng, Z.; McGee, W. M.; Bu, J.; Barefoot, N. Z.; McLuckey, S. A. Gas phase reactivity of carboxylates with N-hydroxysuccinimide esters. J. Am. Soc. Mass. Spectrom. 2015, 26 (1), 174-180.

Otras referencias

Beilstein
113913
Código de tarifa arancelaria unificado
2925.19
TSCA
Yes

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