A11630 1-Bromo-4-fluorobenzene, 99%
FDS
| Tamaño | Precio ($) | Cantidad | Disponibilidad |
|---|---|---|---|
| 100g | 43,20 |
|
|
| 500g | 130,00 |
|
|
| 2500g | 510,00 |
|
|
1-Bromo-4-fluorobenzene, 99%
Propiedades químicas
Aplicaciones
1-Bromo-4-fluorobenzene is used as an intermediate in the synthesis of atypical antipsychotic agents.
Notas
Referencias documentales
Xi-Bin Gu.; Guang-Jun Wang.; Jian-Hua Huang.; Ke-Li Han.; Guo-Zhong He.; Nan-Quan Lou. Photofragment Translational Spectroscopy of 1-Bromo-3-fluorobenzene and 1-Bromo-4-fluorobenzene at 266 nm. J. Phys. Chem. 2001, 105, (2), 354-362.
Kuniaki Kawataa.; Tsuyoshi Ibarakia.; Akiko Tanabea.; Hiroaki Yagoha.; Akiko Shinodab.; Hiroshi Suzukib.; Akio Yasuhara. Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt. Journal of Chromatography A. 2001, 911, (1), 75-83.
The Br undergoes selective displacement with Na alkoxides in NMP, in the presence of CuBr: Tetrahedron, 48, 3633 (1992).
Lithiation with LDA at -75o results mainly in deprotonation ortho to F; subsequent reaction with CO2 gives 5-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 33, 7495 (1992). Improved yields are obtained by the use of Li 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).
Indicaciones de peligro y de precaución del GHS
Indicaciones de peligro (UE): H226-H332-H319
Flammable liquid and vapour. Harmful if inhaled. Causes serious eye irritation.
Indicaciones de precaución: P261-P305+P351+P338
Avoid breathing dust/fume/gas/mist/vapours/spray. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
