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7087-68-5 - N-Ethyldiisopropylamine, 99% - DIEA - N,N-Diisopropylethylamine - A11801 - Alfa Aesar

A11801 N-Ethyldiisopropylamine, 99%

Número CAS
7087-68-5
Nombre Alternativo
DIEA
N,N-Diisopropylethylamine

Tamaño Precio ($) Cantidad Disponibilidad
100ml 33,30
500ml 107,44
2500ml 387,28
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

N-Ethyldiisopropylamine, 99%

MDL
MFCD00008868
EINECS
230-392-0

Propiedades químicas

Fórmula
C8H19N
Peso molecular
129.25
Punto de fusión
-46°
Punto de ebullición
126-127°
Punto de inflamabilidad
8°(46°F)
Densidad
0.747
Índice de refracción
1.4135
Solubilidad
Miscible with water and ethanol.

Aplicaciones

N-Ethyldiisopropylamine is used to make or formulate industrial products. It is also used in organic chemistry as a base. It acts as a selective reagent in the alkylation of secondary amines to tertiary amines by alkyl halides. It reacts with monoactivated Michael acceptors to afford symmetrical sulfones. Further, it is used to prepare heterocyclic compound, sscorpionine by a reaction with disulfur dichloride using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a catalyst.

Notas

Incompatible with acids, acid chlorides, acid anhydrides, carbon dioxide, copper, brass, rubber, oxidizing agents, nitrates, peroxides, aldehydes and metals.

Referencias documentales

Hindered non-nucleophilic base with high proton affinity: Chem. Ber., 91, 380 (1958).

For use in the introduction of TBDMS protecting groups, see tert-Butyl­dimethyl­chlorosilane, A13064 . Used in preparation of silyl enol ethers from both aldehydes and ketones: Helv. Chim. Acta, 60, 181 (1977).

Useful base in peptide coupling reactions: J. Am. Chem. Soc., 91, 6488 (1969). See Appendix 6.

Has been recommended as a base for the Horner-Wadsworth-Emmons olefination reaction, where the reagents contain groups sensitive to base-catalyzed epimerization or condensation. The reaction is carried out in the presence of LiCl, and gives high (E):(Z) ratios: Tetrahedron Lett., 25, 2183 (1984).

Vembu, S.; Pazhamalai, S.; Gopalakrishnan, M. Potential antibacterial activity of triazine dendrimer: Synthesis and controllable drug release properties. Bioorg. Med. Chem. 2015, 23 (15), 4561-4566.

Manandhar, Y.; Bahadur, K. C. T.; Wang, W.; Uzawa, T.; Aigaki, T.; Ito, Y. In vitro selection of a peptide aptamer that changes fluorescence in response to verotoxin. Biotechnol. Lett 2015, 37 (3), 619-625.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H225-H331-H302-H314-H318-H402-H412

Highly flammable liquid and vapour. Toxic if inhaled. Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage. Harmful to aquatic life. Harmful to aquatic life with long lasting effects.

Indicaciones de precaución: P210-P260-P261-P273-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
605301
Clase de peligro
6.1
Grupo de embalaje
I
Código de tarifa arancelaria unificado
2921.19
TSCA
Yes

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