Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

70-34-8 - 1-Fluoro-2,4-dinitrobenzene, 99% - 2,4-Dinitrofluorobenzene - Sanger's Reagent - A11871 - Alfa Aesar

A11871 1-Fluoro-2,4-dinitrobenzene, 99%

Número CAS
70-34-8
Nombre Alternativo
2,4-Dinitrofluorobenzene
Sanger's Reagent

Tamaño Precio ($) Cantidad Disponibilidad
5g 26,60
25g 69,60
100g 186,00
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

1-Fluoro-2,4-dinitrobenzene, 99%

MDL
MFCD00007056
EINECS
200-734-3

Propiedades químicas

Fórmula
C6H3FN2O4
Peso molecular
186.10
Punto de fusión
24-30°
Punto de ebullición
296°
Punto de inflamabilidad
>110°(230°F)
Densidad
1.482
Índice de refracción
1.5690
Solubilidad
Soluble in chloroform, benzene, ether and propylene glycol.

Aplicaciones

1-Fluoro-2,4-dinitrobenzene is used to identify the amino acid sequence. It reacts with amino group of amino acids to yield dinitrophenyl-amino acids. It is also used in chromatographic methods. Further, it acts as an alkylating agent used in elucidating amino acid sequence in proteins.

Notas

Moisture sensitive. Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Referencias documentales

The activated fluoro-substituent is readily displaced by nucleophiles under mild conditions. The anomeric center of a carbohydrate has been protected as the 2,4-dinitrophenyl ether in the presence of DABCO in DMF: Rec. Trav. Chim., 99, 355 (1980).

Used for labelling terminal amino acids in peptides: Biochem. J., 45, 563 (1949); Biochemistry, 20, 512 (1981).

Has been used as a means of protection for the thiol group. The resulting thioether can be cleaved quantitatively with 2-mercaptoethanol: Biochem. Biophys. Res. Commun., 29, 178 (1967).

Can also be used for the masking of the imidazole ring in histidine as the 2,4-dinitrophenyl derivative during peptide synthesis, introduced in the presence of, e.g. K2CO3: Biochem. Biophys. Acta., 82, 412 (1964). The group can be cleaved by treatment with thioglycolic acid, mercaptoethanol, dithiothreitol or thiophenol: Biochem. Biophys. Res. Commun., 29, 178 (1967); Biochemistry, 9, 5122 (1970). The electron withdrawing character of the group has been shown to reduce racemization promoted by the imidazole function: J. Biol. Chem., 247, 4768 (1972). See Appendix 6.

Harifi-Mood, A. R.; Faramarzi, F.; Mehrabi, Y. Investigation of solvent effects on the reaction of 1-fluoro-2,4-dinitrobenzene with aniline in molecular-molecular and ionic liquid-molecular solvent mixtures. Prog. React. Kinet. Mec. 2015, 40 (1), 35-47.

Jalalizadeh, H.; Raei, M.; Tafti, R. F.; Farsam, H.; Kebriaeezadeh, A.; Souri, E. A Stability-Indicating HPLC Method for the Determination of Memantine Hydrochloride in Dosage Forms through Derivatization with 1-Fluoro-2,4-dinitrobenzene. Sci. Pharm. 2014, 82 (2), 265-279.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H301-H311-H331-H315-H317-H318-H341

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. May cause an allergic skin reaction. Causes serious eye damage. Suspected of causing genetic defects.

Indicaciones de precaución: P201-P261-P280-P281-P301+P310-P305+P351+P338-P361-P304+P340-P405-P501a

Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,4172
Beilstein
398632
Clase de peligro
6.1
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2904.90
TSCA
Yes
RTECS
CZ7800000

Recomendado

  • A10164

    Catechol, 99%
  • A10624

    4'-Isobutylacetophenone, 97%
  • A13172

    Ethyl 4-hydroxybenzoate, 99%
  • A15364

    4-Methoxybenzaldehyde, 98%
  • 40476

    Bismuth hydroxide nitrate oxide, Bi<sub>2</sub>O<sub>3</sub> 79% min

Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales

Catalizadores

Análisis y material de laboratorio