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6112-76-1 - 6-Mercaptopurine monohydrate, 98% - 6-Purinethiol monohydrate - A12197 - Alfa Aesar

A12197 6-Mercaptopurine monohydrate, 98%

Número CAS
6112-76-1
Nombre Alternativo
6-Purinethiol monohydrate

Tamaño Precio ($) Cantidad Disponibilidad
1g 20,50
5g 61,50
25g 226,00
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6-Mercaptopurine monohydrate, 98%

MDL
MFCD03854445
EINECS
200-037-4

Propiedades químicas

Fórmula
C5H4N4S•H2O
Peso molecular
170.19 (152.17anhy)
Punto de fusión
ca 315° dec.
Solubilidad
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.

Aplicaciones

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.

Notas

Store in cool, dry place, in well sealed container. Store away from oxidizing agents.

Referencias documentales

K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.

John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H341-H361-H302

Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Indicaciones de precaución: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,5871
Beilstein
4012091
Código de tarifa arancelaria unificado
2933.59
TSCA
No
RTECS
UP0400000

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