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300-87-8 - 3,5-Dimethylisoxazole, 99% - A12217 - Alfa Aesar

A12217 3,5-Dimethylisoxazole, 99%

Número CAS
300-87-8
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
25g 42,00
100g 129,00
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3,5-Dimethylisoxazole, 99%

MDL
MFCD00003156
EINECS
206-100-2

Propiedades químicas

Fórmula
C5H7NO
Peso molecular
97.12
Punto de fusión
-14°
Punto de ebullición
142-144°
Punto de inflamabilidad
31°(87°F)
Densidad
0.992
Índice de refracción
1.4415
Solubilidad
Insoluble in water.

Aplicaciones

The optimization of 3,5-dimethylisoxazole derivatives to develop potent inhibitors of the BET (bromodomain and extra terminal domain) bromodomain family with good ligand efficiency. It has hypoglycemic activity.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Referencias documentales

Hewings DS; Fedorov O; Filippakopoulos P.; Martin S.; Picaud S.; Tumber A.; Wells C.; Olcina MM.; Freeman K.; Gill A.; Ritchie AJ.; Sheppard DW.; Russell AJ.; Hammond EM; Knapp S; Brennan PE; Conway SJ.Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem. 2013, 56 (8), 3217-27.

William E. Dulin; George C. Gerritsen. Hypoglycemic Activity of 3,5 Dimethylisoxazole. Exp Biol Med. 1963, 113 (3), 683-685.

Lithiation occurs first at the 5-methyl group. Subsequent reaction with electrophiles can be followed by further lithiation of the 3-methyl, providing a route to substituted isoxazoles, and also to 1,3-diketones by acid hydrolysis or ß-aminoketones by hydrogenolysis: Tetrahedron Lett., 22, 3699 (1981):

Review: Reaction of 3,5-dimethylisoxazole with some electrophiles: Heterocycles, 6, 805 (1977).

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H226

Flammable liquid and vapour.

Indicaciones de precaución: P210-P280-P240-P241-P233-P242-P243-P303+P361+P353-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Keep container tightly closed. Use only non-sparking tools. Take precautionary measures against static discharge. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
106324
Clase de peligro
3
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2934.99
TSCA
Yes
RTECS
NY2774200

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