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110-89-4 - Piperidine, 99% - A12442 - Alfa Aesar

A12442 Piperidine, 99%

Número CAS
110-89-4
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
100ml 23,40
500ml 53,80
2500ml 185,00
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Piperidine, 99%

MDL
MFCD00005979
EINECS
203-813-0

Propiedades químicas

Fórmula
C5H11N
Peso molecular
85.15
Punto de fusión
-11°
Punto de ebullición
105-106°
Punto de inflamabilidad
3°(37°F)
Densidad
0.862
Índice de refracción
1.4520
Sensibilidad
Air Sensitive
Solubilidad
Miscible with ethanol, water,ethyl ether, acetone, benzene and chloroform

Aplicaciones

Extensively finds applications as a base, a nucleophile and a solvent. Used for the production of dipiperidinyl dithiuram tetrasulfide, which is used as a rubber vulcanization accelerator. It is commonly used in solid phase peptide synthesis (F-MOC Chemistry) and in chemical degradation reactions (sequencing of DNA). Used in making rubber, curing epoxy resins and in fine chemicals, and pharmaceuticals.

Notas

The piperidine skeleton is present in several naturally occuring alkaloids, such as piperine, solenopsin, coniine, etc., and in a wide variety of pharmaceuticals, such as SSRI (Selective Serotonin Reuptake Inhibitors), Vasodilators, SERM (Selective Estrogen Receptor Modulators), Neuroleptics (Antipsychotics), Analeptics/Nootropics (Stimulants), etc. Piperidine is a strong organic base and reacts violently with oxidizers.

Referencias documentales

Rubiralta, M.; Giralt, E.; Diez, A. Piperidine: structure, preparation, reactivity, and synthetic applications of piperidine and its derivatives; Elsevier Science: Burlington, 2013; 460 p.

Srivastava, K.; Davis, M. A comparative examination of two Fmoc removal reagents for process improvement to produce peptide drugs. Adv. Exp. Med. Biol. 2009, 611, 585-91.

Base catalyst in the Doebner modification of the Knoevenagel condensation; see Malonic acid, A11526.

Widely used for cleavage of Fmoc protecting groups: J. Org. Chem., 52, 1197 (1987); Tetrahedron Lett., 34, 6135 (1993). See Appendix 6.

For preparation of the piperidine enamine of cyclooctanecarboxaldehyde, and its subsequent use in the synthesis of spirohexadienones, see: Org. Synth. Coll., 7, 473 (1990).

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H225-H311-H331-H314

Highly flammable liquid and vapour. Toxic in contact with skin. Toxic if inhaled. Causes severe skin burns and eye damage.

Indicaciones de precaución: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,7468
Beilstein
102438
Clase de peligro
8
Grupo de embalaje
I
Código de tarifa arancelaria unificado
2933.32
TSCA
Yes
RTECS
TM3500000

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