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2226-96-2 - 4-Hydroxy-TEMPO, free radical, 98+% - 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical - A12497 - Alfa Aesar

A12497 4-Hydroxy-TEMPO, free radical, 98+%

Número CAS
2226-96-2
Nombre Alternativo
4-Hydroxy-2,2,6,6-tetramethyl-1-piperidin-1-yloxy, free radical

Tamaño Precio ($) Cantidad Disponibilidad
1g 25,10
5g 67,00
25g 261,00
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4-Hydroxy-TEMPO, free radical, 98+%

MDL
MFCD00006478
EINECS
218-760-9

Propiedades químicas

Fórmula
C9H18NO2
Peso molecular
172.25
Punto de fusión
69-72°
Punto de inflamabilidad
146°(295°F)
Solubilidad
Soluble in water, ethanol, methanol and dimethyl sulfoxide.

Aplicaciones

Superoxide scavenger with neuroprotective, anti-inflammatory and analgesic effects4-Hydroxy-TEMPO free radical is used as a catalyst and a chemical oxidant by virtue of being a stable radical. It is used for detoxifying reactive oxygen species in medicinal chemistry. It is involved in the catalysis of disproportionation of superoxide and facilitates hydrogen peroxide metabolism. It is used to prepare tris(2,2,6,6-tetramethyl-1-oxyl-4-piperidyloxy)trimellitate by reacting with benzene-1,2,4-tricarbonyl trichloride. Further, it is used as a free radical scavenger and exhibits neuroprotective, anti-inflammatory and analgesic effects. In addition to this, it has good inhibition effect to acrylic acid esters, methyl acrylate, acrylic acid, acrylonitrile, styrene and butadiene.

Notas

Store in a cool place. Incompatible with strong oxidizing agents.

Referencias documentales

Reviews: Synthesis and reactions of stable nitroxyl radicals: Synthesis, 190, 401 (1971); Advances in the chemistry of nitroxide spin labels: Chem. Rev., 78, 37 (1978); Recent advances in the chemistry of nitroxides and their applications in spin labelling: J. Sci. Ind. Res., 54, 623 (1995). For a brief feature on derived oxoammonium salts, see: Synlett, 1757 (2003).

Compare also 4-Acetamido-TEMPO, B23456 and TEMPO, A12733.

Recommended as a stabilizer (antioxidant) for the protection of unsaturated fatty acids and their derivatives: J. Am. Chem. Soc., 101, 6748 (1979).

żamoj?, K.; Wiczk, W.; Zaborowski, B.; Jacewicz, D.; Chmurzyński, L. Analysis of Fluorescence Quenching of Coumarin Derivatives by 4-Hydroxy-TEMPO in Aqueous Solution. J. Fluoresc. 2014, 24 (3), 713-718.

żamoj?, K.; Zdrowowicz, M.; Wiczk, W.; Jacewicz, D.; Chmurzyński, L. Dihydroxycoumarins as highly selective fluorescent probes for the fast detection of 4-hydroxy-TEMPO in aqueous solution. RSC Adv. 2015, 5 (78), 63807-63812.

Sunkaria, A.; Sharma, D. R.; Wani, W. Y.; Gill, K. D. Attenuation of Dichlorvos-Induced Microglial Activation and Neuronal Apoptosis by 4-Hydroxy TEMPO. Mol. Neurobiol. 2014, 49 (1), 163-175.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H302-H315-H318-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.

Indicaciones de precaución: P280-P305+P351+P338-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor

Otras referencias

Beilstein
1422990
Código de tarifa arancelaria unificado
2933.39
TSCA
Yes
RTECS
TN8991000

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