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345909-35-5 - 4-Hydroxyquinoline-2-carboxylic acid hydrate, 98% - Kynurenic acid - A12602 - Alfa Aesar

A12602 4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

Número CAS
345909-35-5
Nombre Alternativo
Kynurenic acid

Tamaño Precio ($) Cantidad Disponibilidad
1g 19,28
5g 81,58
25g 354,32
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4-Hydroxyquinoline-2-carboxylic acid hydrate, 98%

MDL
MFCD00006753
EINECS
207-751-5

Propiedades químicas

Fórmula
C10H7NO3•xH2O
Peso molecular
189.17(anhy)
Punto de fusión
ca 275° dec.
Solubilidad
Soluble in hot ethanol and water. Insoluble in ether. 

Aplicaciones

Broad spectrum excitatory amino acid antagonist4-Hydroxyquinoline-2-carboxylic acid hydrate is used as an intermediate in synthetic chemistry. It acts as an antiexcitotoxic and anticonvulsant. It finds application in certain neurobiological disorders therapy.

Notas

Incompatible with oxidizing agents.

Referencias documentales

Pesek, J.; Svoboda, J.; Sattler, M.; Bartram, S.; Boland, W. Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis. Org. Biomol. Chem. 2015, 13 (1), 178-184.

Tajti, J.; Majlath, Z.; Szok, D.; Csati, A.; Toldi, J.; Fulop, F.; Vecsei, L. Novel Kynurenic Acid Analogues in the Treatment of Migraine and Neurodegenerative Disorders: Preclinical Studies and Pharmaceutical Design. Curr. Pharm. Des. 2015, 21 (17), 2250-2258.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,5327
Beilstein
147451
Código de tarifa arancelaria unificado
2933.49
TSCA
No
RTECS
VB2080000

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