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1118-02-1 - Trimethylsilyl isocyanate, 94% - A12633 - Alfa Aesar

A12633 Trimethylsilyl isocyanate, 94%

Número CAS
1118-02-1
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
10g 74,57
50g 295,61
250g 980,80
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Trimethylsilyl isocyanate, 94%

MDL
MFCD00001993
EINECS
214-256-8

Propiedades químicas

Fórmula
C4H9NOSi
Peso molecular
115.21
Punto de fusión
-49°
Punto de ebullición
90-92°
Punto de inflamabilidad
-2°(28°F)
Densidad
0.859
Índice de refracción
1.3960
Sensibilidad
Moisture Sensitive
Solubilidad
Miscible with ethers and o-dichlorobenzene.

Aplicaciones

Trimethylsilyl isocyanate is used in the preparation of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones. It finds application in the carbamoylation of aromatic hydrocarbons and alcohols. It is also used in the preparation of primary amides from Grignard reagents. Further, it is used in the synthesis of cyclic imides. It is also utilized for the synthesis of trifluoroacetyl isocyanate and cyclic imides. In addition to this, it is employed in the conversion of isocyanates to carbodiimides using cyclopentadienyl Mn(CO)<sub>3</sub> catalysis.

Notas

Moisture sensitive. Incompatible with strong oxidizing agents, acids, strong bases, alcohols and amines.

Referencias documentales

Convenient protected form of "HNCO". For reactions of isocyanates, see Appendix 3. Reaction with Grignard reagents leads to primary carboxamides: Tetrahedron Lett., 981 (1975).

Eriksson, J.; Kooij, R. V.; Schuit, R. C.; Froklage, F. E.; Reijneveld, J. C.; Hendrikse, N. H.; Windhorst, A. D. Synthesis of [3-N-11C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [11C]methyl iodide. J. Labelled Comp. Radiopharm. 2015, 58 (3), 122-126.

Iwata, Y.; Ando, K.; Taniguchi, K.; Koba, N.; Sugiura, A.; Sudo, M. Identification of a highly potent and selective CB2 agonist, RQ-00202730, for the treatment of irritable bowel syndrome. Bioorg. Med. Chem. Lett. 2015, 25 (2), 236-240.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H225-H330-H315-H319-H335-H334

Highly flammable liquid and vapour. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Indicaciones de precaución: P210-P260-P284-P285-P303+P361+P353-P304+P340-P305+P351+P338-P320-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear respiratory protection. In case of inadequate ventilation wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
1744962
Clase de peligro
3
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2931.90
TSCA
Yes

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