Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

58479-61-1 - tert-Butyldiphenylchlorosilane, 97% - tert-Butylchlorodiphenylsilane - tert-Butyldiphenylsilyl chloride - A12721 - Alfa Aesar

A12721 tert-Butyldiphenylchlorosilane, 97%

Número CAS
Nombre Alternativo
tert-Butyldiphenylsilyl chloride

Tamaño Precio ($) Cantidad Disponibilidad
10g 42,00
50g 130,00
250g 539,00
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

tert-Butyldiphenylchlorosilane, 97%


Propiedades químicas

Peso molecular
Punto de ebullición
Punto de inflamabilidad
Índice de refracción
Moisture Sensitive
Miscible with chloroform and ethyl acetate. Immiscible with water.


tert-Butyldiphenylchlorosilane acts as a silylating reagent used to protect alcohols and in the preparation of silyl ethers. It plays a major role as a raw material and a precursor in organic synthesis and pharmaceuticals. It is also used for the synthesis of interphenylene phenyloxazoles which can be used for the treatment of circulatory disorders, angina and stroke.


Moisture sensitive. Incompatible with strong oxidizing agents, water and bases.

Referencias documentales

Silylating agent (see Appendix 4) for the formation, with e.g. imidazole, of t-butyldiphenylsilyl (TBDPS) ethers of alcohols: Can. J. Chem., 53, 2975 (1975); Org. Synth. Coll., 9, 139 (1998). Alternative to tert-Butyl­dimethyl­chlorosilane, A13064, allowing selective protection of primary alcohols in the presence of secondary, using DMAP/ pyridine: Helv. Chim. Acta, 69, 1273 (1986), or DMAP/ triethylamine: Tetrahedron Lett., 99 (1979); 26, 1185 (1985). TBDPS ethers tend to be more crystalline and are much more stable to acidic conditions than TBDMS. They can also survive acetal formation and cleavage, as well as the acidic conditions required for cleavage of trityl and THP ethers. Silylation rates of hindered alcohols have been increased in the presence of silver nitrate: J. Am. Chem. Soc., 116, 5050 (1994).

Cleavage occurs readily with TBAF in THF: Org. Synth. Coll., 9, 4 (1998). For use of K10 clay in aqueous MeOH, see: J. Org. Chem., 61, 9026 (1996). Cleavage with BBr3 leads directly to the corresponding alkyl bromides: J. Org. Chem., 53, 3111 (1988).

The silyl copper species derived from the lithio-derivative and CuCN adds to terminal alkynes, giving vinyl copper intermediates which react with electrophiles to give vinyl silanes. The presence of the hindered TBDPS group confers some useful differences in comparison with less hindered silyl groups: J .Chem. Soc., Perkin 1., 1525 (1995); compare Chlorodimethyl­phenyl­silane, A15638. The hindered TBDPS group has also been utilized in the Peterson olefination reaction to promote high (Z)-selectivity: Synthesis, 1223 (2000).

Clement, L. L.; Tsakos, M.; Schaffert, E. S.; Scavenius, C.; Enghild, J. J.; Poulsen, T. B. The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile-development of a general synthetic strategy. Chem. Commun. 2015, 51 (62), 12427-12430.

Liu, Y.; Wang, S. Q.; Zhao, B. X. A novel pyrazoline-based fluorescent probe for detecting fluoride ion in water and its application on real samples. RSC Adv. 2015, 5 (42), 32962-32966.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P280-P303+P361+P353-P305+P351+P338-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Otras referencias

Clase de peligro
Grupo de embalaje
Código de tarifa arancelaria unificado


Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales


Análisis y material de laboratorio