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91-01-0 - Benzhydrol, 99% - Diphenylcarbinol - Diphenylmethanol - A12884 - Alfa Aesar

A12884 Benzhydrol, 99%

Número CAS
91-01-0
Nombre Alternativo
Diphenylcarbinol
Diphenylmethanol

Tamaño Precio ($) Cantidad Disponibilidad
50g 18,64
250g 48,31
1000g 154,50
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Benzhydrol, 99%

MDL
MFCD00004488
EINECS
202-033-8

Propiedades químicas

Fórmula
C13H12O
Peso molecular
184.24
Punto de fusión
64-68°
Punto de ebullición
297-298°
Punto de inflamabilidad
160°(320°F)
Solubilidad
Slightly soluble in water.

Aplicaciones

Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.

Notas

Incompatible with strong oxidizing agents, acids, acid chlorides and acid anhydrides.

Referencias documentales

The protection of OH groups as benzhydryl ethers can be catalyzed by sulfuric acid: Org. Synth. Coll., 4, 72 (1963); Angew. Chem. Int. Ed., 15, 281 (1976). See also Benzhydryl­ bromide, L02211. Thiols, e.g. in cysteine residues in peptide synthesis, can be protected as thioethers in the presence of TFA or HBr/AcOH: J. Chem. Soc. (C), 2683 (1970). The group can be cleaved by TFA in the presence of a cation scavenger, e.g. phenol or anisole (same ref.), or by Na in liquid NH3: J. Am. Chem. Soc., 84, 3887 (1962). See Appendix 6.

Carboxyl groups can be protected by esterification in benzene with tosic acid catalyst. Deprotection can be effected with the same catalyst by refluxing in toluene, which undergoes electrophilic alkylation: Tetrahedron Lett., 37, 1965 (1996).

Misawa, T.; Dodo, K.; Ishikawa, M.; Hashimoto, Y.; Sagawa, M.; Kizaki, M.; Aoyama, H. Structure-activity relationships of benzhydrol derivatives based on 1'-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-κB pathway. Bioorg. Med. Chem. 2015, 23 (9), 2241-2246.

Taskin, O. S.; Temel, B. A.; Tasdelen, M. A.; Yagci, Y. Synthesis of block copolymers by selective H-abstraction and radical coupling reactions using benzophenone/benzhydrol photoinitiating system. Eur. Polym. J. 2015, 62, 304-311.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335-H303

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,1090
Beilstein
1424379
Código de tarifa arancelaria unificado
2906.29
TSCA
Yes
RTECS
DC7452000

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