Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

701-99-5 - Phenoxyacetyl chloride, 98% - A13761 - Alfa Aesar

A13761 Phenoxyacetyl chloride, 98%

Número CAS
701-99-5
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
50g 52,70
250g 169,00
1000g 548,00
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

Phenoxyacetyl chloride, 98%

MDL
MFCD00000726
EINECS
211-862-4

Propiedades químicas

Fórmula
C8H7ClO2
Peso molecular
170.60
Punto de ebullición
225-226°
Punto de inflamabilidad
108°(226°F)
Densidad
1.235
Índice de refracción
1.5340
Sensibilidad
Moisture Sensitive
Solubilidad
Reacts with water.

Aplicaciones

Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.

Notas

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, moisture.

Referencias documentales

Ajay K. Bose,; J. C. Kapur,; J. L. Fahey,; M. S. Manhas. Lactams. XXIX. Synthesis of aza analogs of cepham . J. Org. Chem., . 1973, 38(19), 3437-3438.

John C. Sheehan,; Kenneth R. Henery-Logan. The Total Synthesis of Penicillin V. J. Am. Chem. Soc., 1959, 81(12), 3089-3094.

Can be used to protect OH groups. The phenoxyacetate group is 50x more labile to aqueous ammonia than acetate: Tetrahedron Lett., 4273 (1968). It can also be cleaved with methanolic t-BuNH 2 : Chem. Lett., 965 (1982).

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
607585
Clase de peligro
8
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2918.99
TSCA
Yes

Recomendado

Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales

Catalizadores

Análisis y material de laboratorio