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10199-89-0 - 4-Chloro-7-nitrobenzofurazan, 99% - 4-Chloro-7-nitrobenzo-2,1,3-oxadiazole - NBD chloride - A14165 - Alfa Aesar

A14165 4-Chloro-7-nitrobenzofurazan, 99%

Número CAS
10199-89-0
Nombre Alternativo
4-Chloro-7-nitrobenzo-2,1,3-oxadiazole
NBD chloride

Tamaño Precio ($) Cantidad Disponibilidad
5g 47,70
25g 194,00
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4-Chloro-7-nitrobenzofurazan, 99%

MDL
MFCD00005808
EINECS
233-496-4

Propiedades químicas

Fórmula
C6H2ClN3O3
Peso molecular
199.56
Punto de fusión
96-100°
Solubilidad
Soluble in methanol, dimethylsulfoxide, dimethylformamide and chloroform.

Aplicaciones

4-Chloro-7-nitrobenzofurazan is used as a derivatizing reagent for chromatography analysis of amino acids and low molecular weight amines. It is utilized in the preparation of fluorescent phospholipid-derivative, hydroxynaphthofurazan and 4-chloro-7-nitrobenzofurazan- didecanoylphosphatidylethanolamine. It serves as a fluorescent reagent to label free sulfhydryls and N-terminals within proteins and trapping agent for cysteine sulfenic acid. It is a sensitive chromogenic and fluorogenic reagent. It reacts with trans-1-methoxy-3-(trimethylsilyloxy)-1,3-butadiene (Danishefsky's diene) to prepare regioselectively the silyl enol ether. Further, it is used to label peptides, proteins and other biomolecules. In addition it is used in the synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine, functionalized hydroxynaphthofurazan and 7-nitrobenzofurazan (NBD)-labeled maleimide.

Notas

Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Referencias documentales

Fluorogenic reagent for amines and thiols: Anal. Biochem., 53, 290 (1973).

Reagent for pre-column derivatization of amines: Anal. Chim. Acta, 130, 377 (1981), 170, 81 (1985); and of imino acids: Anal. Biochem., 138, 390 (1984), allowing detection after HPLC.

Pan, J.; Zhang, Y.; Xu, J.; Liu, J.; Zeng, L.; Bao, G. M. A smart fluorescent probe for simultaneous detection of GSH and Cys in human plasma and cells. RSC Adv. 2015, 5 (118), 97781-97787.

Zhang, Y.; Chen, H.; Chen, D.; Wu, D.; Chen, X.; Liu, S. H.; Yin, J. A fluorescent turn-on H2S-responsive probe: design, synthesis and application. Org. Biomol. Chem. 2015, 13 (38), 9760-9766.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
614212
Código de tarifa arancelaria unificado
2934.99
TSCA
Yes
RTECS
DF8002400

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