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927-80-0 - Ethoxyacetylene, ca 50% w/w in hexanes - Ethyl ethynyl ether - A14245 - Alfa Aesar

A14245 Ethoxyacetylene, ca 50% w/w in hexanes

Número CAS
927-80-0
Nombre Alternativo
Ethyl ethynyl ether

Tamaño Precio ($) Cantidad Disponibilidad
1g 26,06
5g 79,21
25g 301,79
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Ethoxyacetylene, ca 50% w/w in hexanes

MDL
MFCD00009247
EINECS
213-164-5

Propiedades químicas

Fórmula
C4H6O
Peso molecular
70.09
Punto de ebullición
55-56°
Punto de inflamabilidad
-28°(-18°F)
Densidad
0.718
Índice de refracción
1.3800
Solubilidad
Slightly miscible with water.

Aplicaciones

Ethoxyacetylene is used in Arens-van Dorp synthesis to prepare propargyl alcohol via reaction with ketone. In organic synthesis, it undergoes [2+2] cycloaddition reactions with ketenes to give cyclobutenone derivatives. It is also used to prepare alpha, beta-unsaturated esters from ketones by following Meyer-Schuster rearrangement.Used with N-vinylamides and triflic anhydride in a direct, three-component synthesis of pyridines. Also used to prepare α, β-unsaturated esters from ketones via a Meyer-Schuster rearrangement.

Notas

Incompatible with strong oxidizing agents and strong acids.

Referencias documentales

Supplied in solution to reduce polymerization. Quantities offered relate to gross weight of solution.

Undergoes [2+2] cycloaddition reactions with ketenes to give cyclobutenone derivatives: J. Org. Chem., 38, 1451 (1973).

Adds to carbonyl compounds in the presence of ZnBr2: Can. J. Chem., 54, 2310 (1976).

The Grignard reagent, prepared by exchange with ethyl magnesium bromide, adds to carbonyl compounds to give carbinols which rearrange in acid to ɑß-unsaturated acids. Alternatively, partial reduction of the adduct followed by hydrolysis provides a route to ɑß-unsaturated aldehydes: J. Chem. Soc., 1823 (1949); Rec. Trav. Chim., 82, 305 (1963):

Rearrangement by BF3 etherate leads directly to the ethyl ester: Rec. Trav. Chim., 78, 664 (1959); Chem. Lett., 1129 (1981); 241, 1271 (1982). See also Chloroacetaldehyde diethyl­ acetal, L07661.

Has been used as a mild dehydrating agent in peptide synthesis: Rec. Trav. Chim., 77, 1153 (1958), and for conversion of sensitive dicarboxylic acids to their anhydrides: J. Org. Chem., 33, 3808 (1968).

Aleman, G. H. J.; Machado, R. A. R.; Gorls, H.; Baldwin, I. T.; Bolan, W. Synthesis, structural characterization and biological activity of two diastereomeric JA-Ile macrolactones. Org. Biomol. Chem. 2015, 13 (21), 5885-5893.

Henry, C.; Bolien, D.; Ibanescu, B.; Bloodworth, S.; Harrowven, D. C.; Zhang, X.; Craven, A. Generation and Trapping of Ketenes in Flow. Eur. J. Org. Chem. 2015, 2015 (7), 1491-1499.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H225-H304-H361-H373-H315-H303-H401-H411

Highly flammable liquid and vapour. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Causes skin irritation. May be harmful if swallowed. Toxic to aquatic life. Toxic to aquatic life with long lasting effects.

Indicaciones de precaución: P210-P273-P280h-P281-P243-P301+P330+P331-P315-P403+P235

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid release to the environment. Wear protective gloves/clothing. Use personal protective equipment as required. Take precautionary measures against static discharge. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Get immediate medical advice/attention. Store in a well-ventilated place. Keep cool.

Otras referencias

Beilstein
741882
Clase de peligro
3
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2909.19
TSCA
No
RTECS
KN9900000

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