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76-05-1 - Trifluoroacetic acid, biochemical grade, 99.5+% - A14365 - Alfa Aesar

A14365 Trifluoroacetic acid, biochemical grade, 99.5+%

Número CAS
76-05-1
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
50g 43,00
250g 114,00
1000g 355,00
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Trifluoroacetic acid, biochemical grade, 99.5+%

MDL
MFCD00004169
EINECS
200-929-3

Propiedades químicas

Fórmula
CF3CO2H
Peso molecular
114.02
Punto de fusión
-15°
Punto de ebullición
72-73°
Densidad
1.480
Índice de refracción
1.2840
Sensibilidad
Hygroscopic
Solubilidad
Miscible with ether, acetone, ethanol, benzene, hexane and carbon tetrachloride.

Aplicaciones

Used to cleave peptide blocking groupsThe combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Notas

Trifluoroacetic acid (TFA) is a stable, hygroscopic, volatile and low-boiling organic acid. Storage in a cool place is recommended.

Referencias documentales

López, S. E.; Salazar, J. Trifluoroacetic acid: Uses and recent applications in organic synthesis. J. Fluorine Chem. 2013, 156, 73-100.

Natu, A. D.; Burde, A. S.; Limaye, R. A.; Paradkar, M. V. Acceleration of the Dakin reaction by trifluoroacetic acid. J. Chem. Res. 2014, 38 (6), 325-386.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H332-H314

Harmful if inhaled. Causes severe skin burns and eye damage.

Indicaciones de precaución: P260u-P280g-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P363-P405-P501a

Wear protective gloves. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,9681
Beilstein
742035
Clase de peligro
8
Grupo de embalaje
I
Código de tarifa arancelaria unificado
2915.90
TSCA
Yes
RTECS
AJ9625000

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