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4009-98-7 - (Methoxymethyl)triphenylphosphonium chloride, 98+% - A14380 - Alfa Aesar

A14380 (Methoxymethyl)triphenylphosphonium chloride, 98+%

Número CAS
4009-98-7
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
25g 53,40
100g 124,00
500g 449,00
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(Methoxymethyl)triphenylphosphonium chloride, 98+%

MDL
MFCD00011800
EINECS
223-664-5

Propiedades químicas

Fórmula
CH3OCH2P(C6H5)3Cl
Peso molecular
342.81
Punto de fusión
ca 190° dec.
Sensibilidad
Hygroscopic
Solubilidad
Soluble in methanol and chloroform. It decomposes in water.

Aplicaciones

(Methoxymethyl)triphenylphosphonium chloride is used as a phase transfer catalyst and in the synthesis of taxol-A fragment. It is widely used in the synthesis of pharmaceutical product cephalotaxine, which is used as an antiviral and antitumor agent.

Notas

Hygroscopic . Incompatible with strong oxidizing agents.

Referencias documentales

Wittig reaction (see Appendix 1) of the derived phosphorane with aldehydes and ketones gives enol ethers, readily hydrolyzed to homologous aldehydes. For an example (adamantanone to adamantanecarboxaldehyde), see: Chem. Ber., 95, 2514 (1962). For use of the reaction in the synthesis of hydroisoquinoline AMPA antagonists, see: J. Med. Chem., 39, 2219 (1996). Reaction with chiral 2,3-epoxyaldehydes provides an enantioselective synthesis of (E)-4-hydroxyalkenes: J. Chem. Soc., Chem. Commun., 232 (1993).

/n

Lee, K.; Poudel, Y. B.; Glinkerman, C. M.; Boger, D. L. Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs. Tetrahedron 2015, 71 (35), 5897-5905.

Yu, Q.; Ma, S. An Enantioselective Synthesis of (R)-5,6-Octadecadienoic Acid. Eur. J. Org. Chem. 2015, 2015 (7), 1596-1601.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
924215
Código de tarifa arancelaria unificado
2931.39
TSCA
No

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