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144-48-9 - 2-Iodoacetamide, 98%, stab. with ca 5-8% water - A14715 - Alfa Aesar

A14715 2-Iodoacetamide, 98%, stab. with ca 5-8% water

Número CAS
144-48-9
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
5g 21,40
25g 63,20
100g 207,00
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2-Iodoacetamide, 98%, stab. with ca 5-8% water

MDL
MFCD00008028
EINECS
205-630-1

Propiedades químicas

Fórmula
ICH2CONH2
Peso molecular
184.96
Punto de fusión
92-95°(dried)
Sensibilidad
Light Sensitive
Solubilidad
Soluble in water, dimethyl formamide and ethanol. Slightly soluble in methanol.

Aplicaciones

Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.

Notas

Store in a cool place. Light and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Referencias documentales

Zbancioc, G.; Mangalagiu, I. I.; Moldoveanu, C. Ultrasound assisted synthesis of imidazolium salts: An efficient way to ionic liquids. Ultrason. Sonochem. 2015, 23, 376-384.

Moriyama, M.; Metzger, S.; van der Vlies, A. J.; Uyama, H.; Ehrbar, M.; Hasegawa, U. Inhibition of Angiogenesis by Antioxidant Micelles. Adv. Healthcare Mater. 2013, 4 (4), 569-575.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H301-H315-H319-H317-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P363-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
1739080
Clase de peligro
6.1
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2924.19
TSCA
Yes
RTECS
AC4200000

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