The CF3 group promotes ionization of the amino group under basic conditions which also make the CF3 unusually reactive towards nucleophiles. Many examples have been reported by L. Strekowski et al in which various heterocyclic systems have been synthesized. See, e.g.: J. Org. Chem., 59, 5886 (1994); Tetrahedron Lett., 35, 7597 (1994) and refs therein:/n
Indicaciones de peligro (UE): H227-H302-H315-H318-H335-H373
Combustible liquid. Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure.
Indicaciones de precaución: P273-P280-P305+P351+P338-P337+P313
Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.