Methyl crotonate was used to investigate chemo selectivity in the reaction between methyl crotonate and benzyl amine catalyzed by lipase B from Candida Antarctica using solvent engineering. It was used as starting reagent during the total synthesis of phytotoxins solanapyrones D(1) and E(2).
Hajime Kabashima; Hideto Tsuji; Hideshi Hattori. Michael addition of methyl crotonate over solid base catalysts. Applied Catalysis A: General. 1997, 165 (1-2), 319-325.
Robin D. Clark; Karl G. Untch. [2 + 2] Cycloadditions of silyl enol ethers and dimethyl acetylenedicarboxylate, dimethyl fumarate, and methyl crotonate. J. Org. Chem. 1979, 44 (2), 253-255.
Indicaciones de peligro (UE): H225-H315-H319-H335
Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Indicaciones de precaución: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.