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569-58-4 - Aluminon - Aurintricarboxylic acid triammonium salt - A15401 - Alfa Aesar

A15401 Aluminon

Número CAS
569-58-4
Nombre Alternativo
Aurintricarboxylic acid triammonium salt

Tamaño Precio ($) Cantidad Disponibilidad
10g 18,75
50g 60,26
250g 229,04
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Aluminon

MDL
MFCD00040925
EINECS
209-319-1

Propiedades químicas

Fórmula
C22H23N3O9
Peso molecular
473.44
Punto de fusión
220-225° dec.
Solubilidad
Soluble in water(800g/L).

Aplicaciones

It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Referencias documentales

R G González,; R S Haxo,; T Schleich. Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions. Biochemistry (Washington). 1980, 19 (18),4299-4303.

Y Benchokroun,; J Couprie,; A K Larsen. Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells. Biochemical Pharmacology. 1995, 49(3), 305-313.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Indicaciones de precaución: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Otras referencias

Merck
14,322
Código de tarifa arancelaria unificado
2918.99
TSCA
Yes
RTECS
GU4800000

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