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1899-93-0 - m-Toluenesulfonyl chloride, 98% - 3-Methylbenzenesulfonyl chloride - A15458 - Alfa Aesar

A15458 m-Toluenesulfonyl chloride, 98%

Número CAS
1899-93-0
Nombre Alternativo
3-Methylbenzenesulfonyl chloride

Tamaño Precio ($) Cantidad Disponibilidad
1g 23,00
5g 55,10
25g 199,00
100g 653,00
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m-Toluenesulfonyl chloride, 98%

MDL
MFCD00051747

Propiedades químicas

Fórmula
C7H7ClO2S
Peso molecular
190.65
Punto de ebullición
252-253°
Punto de inflamabilidad
107°(224°F)
Densidad
1.314
Índice de refracción
1.5480
Sensibilidad
Moisture Sensitive
Solubilidad
Reacts with water.

Aplicaciones

Reactant involved in they synthesis of biologically active molecules including small molecule ligands for the Stat3 SH2 domain, aryldisulfonamides with antibacterial activity, quinazoline analogs for the treatment of Gaucher disease, 17β-HSD2 inhibitors for the treatment of osteoporosis, isoindoline-5-propenehydroxamates for use as histone deactylase inhibitors.

Notas

Moisture sensitive. Store under inert gas. Store away from moisture, oxidizing agents.

Referencias documentales

Wen-Hsing Lin; Shu-Yi Hsieh; Shih-Chieh Yen; Chiung-Tong Chen; Teng-Kuang Yeh; Tsu Hsu; Cheng-Tai Lu; Ching-Ping Chen; Chun-Wha Chen; Ling-Hui Chou; Yu-Lin Huang; An-Huei Cheng; Yun-I Chang; Ya-Ju Tseng; Kuei-Rong Yen; Yu-Sheng Chao; John T.-A. Hsu; Weir-Torn Jiaang. Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorganic & Medicinal Chemistry. 2011, 19 (14), 4173-4182.

Brent D G Page; Steven Fletcher; Peibin Yue; Zhihua Li; Xiaolei Zhang; Sumaiya Sharmeen; Alessandro Datti; Jeffrey L Wrana; Suzanne Trudel; Aaron D Schimmer; James Turkson; Patrick T Gunning. Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (18), 5605-5609.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
2087865
Clase de peligro
8
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2904.90
TSCA
No

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