Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

36239-09-5 - Ethyl malonyl chloride, 95% - Ethyl (chloroformyl)acetate - Malonic acid monoethyl ester chloride - A15616 - Alfa Aesar

A15616 Ethyl malonyl chloride, 95%

Número CAS
36239-09-5
Nombre Alternativo
Ethyl (chloroformyl)acetate
Malonic acid monoethyl ester chloride

Tamaño Precio ($) Cantidad Disponibilidad
5g 50,40
25g 175,00
100g 561,00
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

Ethyl malonyl chloride, 95%

MDL
MFCD00000736
EINECS
252-934-5

Propiedades químicas

Fórmula
C5H7ClO3
Peso molecular
150.56
Punto de ebullición
83°/22mm
Punto de inflamabilidad
67°(152°F)
Densidad
1.189
Índice de refracción
1.4290
Sensibilidad
Moisture Sensitive
Solubilidad
Miscible with water.

Aplicaciones

Ethyl malonyl chloride is used in the syntheses of methanofullerodendimers and 3-pyrrolin-2-ones. It plays a vital role in the preparation of 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks. It is a versatile acylating agent for propargyl alcohols, hydrazines and amines.

Notas

Store in cool place. Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with alcohols. It reacts with water.

Referencias documentales

Useful synthetic building block, e.g. in an oxazole synthesis: J. Med. Chem., 36, 3871 (1993):

Formation of amides has been used in the syntheses of 1,2,4-triazine-3,6-diones, and of a vicinal tricarbonyl amide derivative of L-phenylalanine: J. Org. Chem., 60, 5992 (1995); 61, 1872 (1996).

Yang, Z.; Li, S.; Zhang, Z.; Xu, J. Base-switched annuloselectivity in the reactions of ethyl malonyl chloride and imines. Org. Biomol. Chem. 2014, 12 (48), 9822-9830.

Hayat, F.; Kang, L.; Lee, C. Y.; Shin, D. Synthesis of arylnaphthalene lignan lactone using benzoin condensation, intramolecular thermal cyclization and Suzuki coupling. Tetrahedron 2015, 71 (19), 2945-2950.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Indicaciones de precaución: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
636215
Clase de peligro
8
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2917.19
TSCA
No

Recomendado

  • A10655

    1-Bromopinacolone, 97+%
  • A13203

    Propionitrile, 99%
  • A13292

    Sodium bis(2-methoxyethoxy)aluminum hydride, 70% w/w in toluene.
  • A13543

    Guanidine hydrochloride, 98%
  • 40191

    Phosphorus(III) bromide, 99% (metals basis)

Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales

Catalizadores

Análisis y material de laboratorio