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5457-28-3 - Indole-3-carbonitrile, 98% - 3-Cyanoindole - A16041 - Alfa Aesar

A16041 Indole-3-carbonitrile, 98%

Número CAS
5457-28-3
Nombre Alternativo
3-Cyanoindole

Tamaño Precio ($) Cantidad Disponibilidad
1g 34,10
5g 121,00
25g 440,00
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Indole-3-carbonitrile, 98%

MDL
MFCD00022717
EINECS
000-000-0

Propiedades químicas

Fórmula
C9H6N2
Peso molecular
142.16
Punto de fusión
177-182°
Sensibilidad
Light Sensitive
Solubilidad
Insoluble in water.

Aplicaciones

Indole-3-carbonitrile is used as a synthesis reagent for preparation of 4-substituted β-lactams, biologically active indoles, inhibitors of glycogen synthase kinase 3β (GSK-3), indole fragments as inosine monophosphate dehydrogenase (IMPDH) inhibitors and HIV-1 integrase inhibitors. It is also used as a reactant for intramolecular oxidative C-H coupling reactions with applications in medium-ring synthesis techniques and for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators.

Notas

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents. It is sensitive to light.

Referencias documentales

Didier G Pintori.; Michael F Greaney. Intramolecular oxidative C-H coupling for medium-ring synthesis. Journal of the American Chemical Society. 2011, 133 (5), 1209-1211.

F Y Miyake.; K Yakushijin, D A Horne. A concise synthesis of topsentin A and nortopsentins B and D. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2000, 2 (14), 2121-2123.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
120888
Código de tarifa arancelaria unificado
2933.99
TSCA
No

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