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491-36-1 - 4-Hydroxyquinazoline, 98% - 4-Quinazolinol - A17129 - Alfa Aesar

A17129 4-Hydroxyquinazoline, 98%

Número CAS
491-36-1
Nombre Alternativo
4-Quinazolinol

Tamaño Precio ($) Cantidad Disponibilidad
10g 31,60
50g 103,00
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4-Hydroxyquinazoline, 98%

MDL
MFCD00511302
EINECS
207-735-8

Propiedades químicas

Fórmula
C8H6N2O
Peso molecular
146.15
Punto de fusión
216-219°
Solubilidad
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

Aplicaciones

4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Referencias documentales

B Veres.; B Radnai.; F Gallyas.; G Varbiro. Regulation of Kinase Cascades and Transcription Factors by a Poly(ADP-Ribose) Polymerase-1 Inhibitor, 4-Hydroxyquinazoline, in Lipopolysaccharide-Induced Inflammation in Mice. JPET . 2004310 (1), 247-255.

JS Morley.; JCE Simpson. 88. The chemistry of simple heterocyclic systems. Part I. Reactions of 6-and 7-nitro-4-hydroxyquinazoline and their derivatives. Journal of the Chemical Society . 194888 (1), 360-366.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P280h-P305+P351+P338

Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Otras referencias

Beilstein
118473
Código de tarifa arancelaria unificado
2933.59
TSCA
No
RTECS
VA2300000

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