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91-13-4 - o-Xylylene dibromide, 97% - 1,2-Bis(bromomethyl)benzene - alpha,alpha'-Dibromo-o-xylene - A17241 - Alfa Aesar

A17241 o-Xylylene dibromide, 97%

Número CAS
91-13-4
Nombre Alternativo
1,2-Bis(bromomethyl)benzene
alpha,alpha'-Dibromo-o-xylene

Tamaño Precio ($) Cantidad Disponibilidad
5g 16,30
25g 56,10
100g 145,00
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o-Xylylene dibromide, 97%

MDL
MFCD00000175
EINECS
202-042-7

Propiedades químicas

Fórmula
C8H8Br2
Peso molecular
263.96
Punto de fusión
92-96°
Densidad
1.960
Solubilidad
Solubility in toluene is almost transparent and ethanol. Insoluble in water.

Aplicaciones

1,2-Bis(bromomethyl)benzene is used in the synthesis of isothioureas involved in the inhibition of human nitric oxide synthases. Also used in the synthesis of tridentate carbene ligands.

Notas

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Referencias documentales

Gary D. Ewing, et al. Efficient synthesis of 4,5-benzotropone from o-xylylene dibromide.J. Org. Chem.,1975,40(20), 2965-2966.

C. E. Griffin, et al. Synthesis of a Macrocycle by Application of the Wittig Reaction.J. Org. Chem.,1962,27(5), 1627-1631.

Reductive debromination with activated Ni provides a simple route to o-xylylene, which can be trapped by dienophiles: J. Org. Chem., 53, 339 (1988):

o-Xylylene can also be generated using Zn metal and ultrasound: J. Org. Chem., 47, 751 (1982), or NaI in DMF: Chem. Pharm. Bull., 22, 2159 (1974).

Dialkylating agent for the formation of a variety of benzo-fused carbocyclic and heterocyclic ring systems, e.g. five-membered with Meldrum's acid (Isopropyl­idene malonate, A15603): Org. Prep. Proced. Int., 24, 185 (1992), 7-membered with Dimethyl­ acetone-1,3-dicarboxyl­ate, A14969: J. Org. Chem., 54, 5237 (1989), as well as macrocycles and cryptands; see, e.g.: J. Org. Chem., 57, 6112 (1992). Reaction with 1,2- and 1,3-diols has been used a method of protection; the diol can be regenerated by hydrogenolysis: Synth. Commun., 19, 3363 (1989).

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P280-P305+P351+P338-P309-P310a

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell:

Otras referencias

Beilstein
637159
Clase de peligro
8
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2903.99
TSCA
Yes

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