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124-20-9 - Spermidine, 99% - N-(3-Aminopropyl)-1,4-diaminobutane - 1,8-Diamino-4-azaoctane - A19096 - Alfa Aesar

A19096 Spermidine, 99%

Número CAS
124-20-9
Nombre Alternativo
N-(3-Aminopropyl)-1,4-diaminobutane
1,8-Diamino-4-azaoctane

Tamaño Precio ($) Cantidad Disponibilidad
1g 26,30
5g 77,60
25g 298,00
100g 675,00
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Spermidine, 99%

MDL
MFCD00008229
EINECS
204-689-0

Propiedades químicas

Fórmula
H2N(CH2)3NH(CH2)4NH2
Peso molecular
145.25
Punto de fusión
22-25°
Punto de ebullición
128-130°/14mm
Punto de inflamabilidad
>110°(230°F)
Densidad
0.925
Índice de refracción
1.4790
Sensibilidad
Air Sensitive
Solubilidad
Miscible with water, ethanol and ether.

Aplicaciones

Binds to the polyamine modulatory site of NMDA Spermidine is used in electroporation during transferring the DNA into the cell under the electrical impulse. It is also used for purification of DNA-binding proteins. It combines with calcium chloride and utilized for the precipitation of DNA onto microprojectiles for bombardment with a gene gun. It plays an important role to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagy. It serves as a precursor of spermine and essential for both normal and neoplastic tissue growth.

Notas

Hygroscopic. Incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.

Referencias documentales

Pietrocola, F.; Lachkar, S.; Enot, D. P.; Niso-Santano, M.; Bravo-San Pedro, J. M.; Sica, V.; Izzo, V.; Maiuri, M C.; Madeo, F.; Mariño, G.; Kroemer, G. Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ. 2015, 22 (3), 509-516.

Ibarra, A. A. G.; Wrobel, K.; Escobosa, A. R. C.; Elguera, J. C. T.; Garay-Sevilla, M. E.; Wrobel, K. Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography-electrospray ionization-ion trap tandem mass spectrometry (HPLC-ESI-ITMS/MS). J. Chromatogr. B 2015, 1002, 176-184.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Indicaciones de precaución: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,8742
Beilstein
1698591
Clase de peligro
8
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2921.29
TSCA
Yes
RTECS
EJ7000000

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