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57-66-9 - Probenecid, 98% - 4-(Di-n-propylaminosulfonyl)benzoic acid - 4-(Di-n-propylsulfamoyl)benzoic acid - B20010 - Alfa Aesar

B20010 Probenecid, 98%

Número CAS
57-66-9
Nombre Alternativo
4-(Di-n-propylaminosulfonyl)benzoic acid
4-(Di-n-propylsulfamoyl)benzoic acid

Tamaño Precio ($) Cantidad Disponibilidad
2.5g 49,30
10g 148,00
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Probenecid, 98%

MDL
MFCD00038402
EINECS
200-344-3

Propiedades químicas

Fórmula
C13H19NO4S
Peso molecular
285.36
Punto de fusión
198-199°
Solubilidad
Soluble in water (partly miscible), solutions of alkali hydroxides,, ethanol (100 mM), acetone, chloroform, sodium hydroxide (1 M), DMSO (100 mM), methanol, dilute acids (practically insoluble), dilute alkalies, and ether (slightly soluble).

Aplicaciones

It is a uricosuric drug, that is, it increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia. Probenecid was developed as an alternative to caronamide to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and prolonging their effects.

Notas

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Referencias documentales

Campos-Arroyo D, et al. Probenecid is a chemosensitizer in cancer cell lines.Cancer chemotherapy and pharmacology.1992,69(2), 495-504.

Robbins N, et al. The history and future of probenecid.Cardiovascular toxicology.2012,12(1), 1-9.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P260u-P201-P280a-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves and eye/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,7754
Código de tarifa arancelaria unificado
2935.90
TSCA
Yes
RTECS
DG9400000

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