Cookies disclaimer

Estoy de acuerdo utilizamos cookies para mejorar la experiencia de navegación del usuario y para estudiar cómo se utiliza nuestro sitio web. si navega por nuestro sitio web, estará aceptando el uso de las cookies en las condiciones establecidas en la presente política de cookies. esta política puede ser actualizada, por lo que le invitamos a revisarla de forma regular

2916-68-9 - 2-(Trimethylsilyl)ethanol, 98+% - 2-Hydroxyethyltrimethylsilane - B20970 - Alfa Aesar

B20970 2-(Trimethylsilyl)ethanol, 98+%

Número CAS
2916-68-9
Nombre Alternativo
2-Hydroxyethyltrimethylsilane

Tamaño Precio ($) Cantidad Disponibilidad
5g 72,10
25g 245,14
100g 771,47
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

2-(Trimethylsilyl)ethanol, 98+%

MDL
MFCD00002825
EINECS
220-844-5

Propiedades químicas

Fórmula
(CH3)3SiCH2CH2OH
Peso molecular
118.25
Punto de ebullición
71-72°/10mm
Punto de inflamabilidad
50°(122°F)
Densidad
0.825
Índice de refracción
1.4250
Solubilidad
Miscible with water.

Aplicaciones

2-(Trimethylsilyl)ethanol is used as a protecting reagent for carboxyl, phosphoryl, hydroxyl and amino group in organic synthesis. It is used as a precursor to prepare trimethyl(2-phenoxyethyl)silanes by reacting with aromatic fluoride. It is also used in the synthesis of teoc-protected amines by using the corresponding isocyanates.

Notas

Keep away from sources of ignition. Keep container tightly closed in a dry and well-ventilated place.

Referencias documentales

Carboxyl groups can be protected as 2-(trimethylsilyl)ethyl (TMSE) esters by carbodiimide coupling: Helv. Chim. Acta, 60, 2711 (1977); J. Org. Chem., 62, 93 (1997), from the acid chloride in pyridine: Helv. Chim. Acta, 60, 3039 (1977), or refluxing the acid in THF in the presence of TMS chloride: J. Am. Chem. Soc., 106, 3030 (1984). The TMSE protecting group is useful in peptide synthesis. Cleavage is readily effected with TBAF in DMF or DMSO: Helv. Chim. Acta, 60, 2711 (1977); Bioorg. Med. Chem. Lett., 3, 437 (1993).

Qu, H.; Sun, W.; Sun, T.; Sollogoub, M.; Zhang, Y. Synthesis and characterization of four novel 2-(trimethylsilyl)ethyl glycosides. Res. Chem. Intermed. 2015, 41 (2), 1107-1113.

Sano, S.; Sumiyoshi, H.; Handa, A.; Tokizane, R.; Nakao, M. A novel synthetic approach to glycerophospholipids via Horner-Wadsworth-Emmons reaction of mixed phosphonoacetate. Tetrahedron Lett. 2015, 56 (32), 4686-4688.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
1732034
Clase de peligro
3
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2931.90
TSCA
No
RTECS
KM5480000

Recomendado

Visto recientemente

Productos químicos

Ciencias de la vida

Metales & materiales

Catalizadores

Análisis y material de laboratorio