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1538-75-6 - Trimethylacetic anhydride, 99% - Pivalic anhydride - B22983 - Alfa Aesar

B22983 Trimethylacetic anhydride, 99%

Número CAS
1538-75-6
Nombre Alternativo
Pivalic anhydride

Trimethylacetic anhydride, 99%

MDL
MFCD00008842
EINECS
216-263-1

Propiedades químicas

Fórmula
C10H18O3
Peso molecular
186.25
Punto de ebullición
193°
Punto de inflamabilidad
63°(145°F)
Densidad
0.918
Índice de refracción
1.4090
Sensibilidad
Moisture Sensitive
Solubilidad
Miscible with acetonitrile.

Aplicaciones

Trimethylacetic anhydride is used as acylation and esterification reagents. It is involved in acylation and esterification reactions with anilines and phenols. It is also used in solid-phase oligonucleotide synthesis and in the kinetic resolution of racemic 2-hydroxy-gamma-butyrolactones with diphenylacetic acid. It is also employed in the production of cyano-4, N-tert-butyloxycarbonyl piperidine.

Notas

Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.

Referencias documentales

The direct hydrogenation of carboxylic acids to aldehydes has been achieved in the presence of pivalic anhydride and Tetrakis(triphenyl­phosphine)­palladium(0)­, 10548 : Chem. Lett., 1143 (1998).

Alcohols can be protected as their pivaloyl (Pv) esters by reaction with the anhydride in the presence of MgBr2 - Et3N or Sc(OTf)3 in acetonitrile: J. Org. Chem., 61, 5702 (1996). See also Trimethyl­acetyl­ chloride, A15051 .

Zhu, J. L.; Liu, Y.; Liu, X. Y.; Liu, H. J.; Chen, Y. Multi stimuli-responsive photoluminescent nanocomposite of silver nanoclusters with hyperbranched polyethylenimine derivatives. RSC Adv. 2015, 5 (11), 8146-8151.

Wu, J.; Leng, W. L.; Liao, H.; Hoang, K. L. M.; Le, K.; Liu, X. W. Intramolecular C-N Bond Formation under Metal-free Conditions: Synthesis of Indolizines. Chem. Asian J. 2015, 10 (4), 853-856.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Indicaciones de precaución: P280-P305+P351+P338-P309-P310

Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER or doctor/physician.

Otras referencias

Beilstein
386552
Clase de peligro
8
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2915.90
TSCA
Yes

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