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496-76-4 - 2,4,5-Trihydroxypyrimidine, 98% - Isobarbituric acid - B23320 - Alfa Aesar

B23320 2,4,5-Trihydroxypyrimidine, 98%

Número CAS
496-76-4
Nombre Alternativo
Isobarbituric acid

2,4,5-Trihydroxypyrimidine, 98%

MDL
MFCD00082987
EINECS
207-829-9

Propiedades químicas

Fórmula
C4H4N2O3
Peso molecular
128.09
Punto de fusión
>300°
Solubilidad
Soluble in DMSO (Sparingly), Methanol (Sparingly).

Aplicaciones

2,4,5-Trihydroxypyrimidine studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. It acts as an antagonist of uracil in the growth of Lactobacillus casei.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials are oxidizing agents.

Referencias documentales

William R Markesbery; Mark A Lovell. DNA oxidation in Alzheimer's disease. Antioxidants and Redox Signaling.2006, 8, (11-12), 2039-2045.

Maria D Aamann; Martin M Sorensen; Christina Hvitby; Brian R Berquist; Meltem Muftuoglu; Jingyan Tian; Nadja C de Souza-Pinto; Morten Scheibye-Knudsen; David M Wilson; Tinna Stevnsner; Vilhelm A Bohr. Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB Journal.2010, 24, (7), 2334-2346.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
127205
Código de tarifa arancelaria unificado
2933.59
TSCA
No

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