B24875 1-Trimethylsilyl-1-propyne, 98%
FDS
| Tamaño | Precio ($) | Cantidad | Disponibilidad |
|---|---|---|---|
| 1g | 40,00 |
|
|
| 5g | 107,00 |
|
|
| 25g | 426,00 |
|
|
1-Trimethylsilyl-1-propyne, 98%
Propiedades químicas
Aplicaciones
1-Trimethylsilyl-1-propyne is employed in the preparation of alkynyl silane derivatives. It is also used to prepare highly substituted indenes using palladium-catalyzed carboannulation. Further, it plays an important role in the preparation of indenones through a rhodium-catalyzed reaction with 2-bromophenylboronic acids.
Notas
Referencias documentales
Alkylation of the lithio-derivative proceeds with only a small amount of allylic rearrangement to the allene, and is thus a useful route to substituted terminal alkynes: Tetrahedron Lett., 5041 (1968):
Trost, B. M.; Koester, D. C.; Herron, A. N. Stereocontrolled Synthesis of Vinyl Boronates and Vinyl Silanes via Atom-Economical Ruthenium-Catalyzed Alkene-Alkyne Coupling. Angew. Chem. Int. Ed. 2015, 127 (52), 16089-16092.
Thakur, A.; Louie, J. Advances in Nickel-Catalyzed Cycloaddition Reactions To Construct Carbocycles and Heterocycles. Acc. Chem. Res. 2015, 48 (8), 2354-2365.
Indicaciones de peligro y de precaución del GHS
Indicaciones de peligro (UE): H225
Highly flammable liquid and vapour.
Indicaciones de precaución: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
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