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65-86-1 - Orotic acid, anhydrous, 97% - 1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid - Uracil-4-carboxylic acid - B25349 - Alfa Aesar

B25349 Orotic acid, anhydrous, 97%

Número CAS
Nombre Alternativo
1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid
Uracil-4-carboxylic acid

Tamaño Precio ($) Cantidad Disponibilidad
100g 84,40
500g 230,00
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Orotic acid, anhydrous, 97%


Propiedades químicas

Peso molecular
Punto de fusión
Slightly soluble in water.


Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5?-phospho-α-d-ribose 1?-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5?-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5?-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.


Stable under recommended storage conditions. Incompatible with oxidizing agents.

Referencias documentales

Eun-Jeong Jung; Sung-Won Kwon; Byung-Hwa Jung; Seon-Hee Oh; Byung-Hoon Lee. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. Journal of Lipid Research. 2011, 52,(9), 1617-1625.


Xing Wang; Xiuwen Wang; Mengxin Yin; Zijun Xiao; Cuiqing Ma; Zhixin Lin; Peng George Wang; Ping Xu. Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process. Applied Microbiology and Biotechnology. 2007, 76,(2), 321-328.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H302-H315-H319

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.

Indicaciones de precaución: P280-P264-P270-P305+P351+P338-P362-P301+P312-P321-P332+P313-P337+P313-P501a

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Código de tarifa arancelaria unificado


  • A15398

    Hydroxylamine hydrochloride, 99%
  • L03521

    Cyclobutyl methyl ketone, 97%
  • 47019

    Palladium, 5% on activated carbon powder, Type A109047-5, standard, reduced, nominally 50% water wet

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