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18107-18-1 - (Trimethylsilyl)diazomethane, 2M in hexanes - (Diazomethyl)trimethylsilane - H26744 - Alfa Aesar

H26744 (Trimethylsilyl)diazomethane, 2M in hexanes

Número CAS
18107-18-1
Nombre Alternativo
(Diazomethyl)trimethylsilane

Tamaño Precio ($) Cantidad Disponibilidad
5ml 58,30
25ml 190,00
100ml 606,00
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(Trimethylsilyl)diazomethane, 2M in hexanes

MDL
MFCD00053946

Propiedades químicas

Fórmula
C4H10N2Si
Peso molecular
114.22
Punto de inflamabilidad
-23°(-10°F)
Densidad
0.718
Sensibilidad
Moisture & Light Sensitive
Solubilidad
Immiscible with water. Miscible with organic solvents.

Aplicaciones

(Trimethylsilyl)diazomethane is used as a methylating agent in organic chemistry. It is utilized in Gas Chromatography- Mass-Spectrometry (GC-MS) for the analysis of various carboxylic compounds. It is involved as a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. It is considered and used as a less-explosive replacement fordiazomethane. It is also used as a reactant for Unnatural alfa-amino acid derivatives containing gem-bisphosphonates through Michael addition reaction, imidazolo[2,1-b]benzothiazole derivatives and aigialomycin D analogues.

Notas

(Trimethylsilyl)diazomethane (TMSD) in alcoholic solvents under acidic or basic conditions can lead to the formation of diazomethane. TMSD is under review by the National Toxicological Program for potential inhalation hazards.Incompatible with oxidizing agents, chlorine, fluorine and perchlorates.

Referencias documentales

Kumar, R.; Turcaud, S.; Micouin, L. The Reaction of Dimethylalkynylaluminum Reagents with Trimethylsilyldiazomethane: Original Reactivity Leading to New alpha-Silylated Alkynyl Hydrazones. 2014, 16 (23), 6192-6195.

Kang, B. C.; Shim, S. Y.; Ryu, D. H. Highly Stereoselective Oxazaborolidinium Ion Catalyzed Synthesis of (Z)-Silyl Enol Ethers from Alkyl Aryl Ketones and Trimethylsilyldiazomethane. 2014, 16 (8), 2077-2079.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H225-H331-H315-H350-H361-H336-H373-H304

Highly flammable liquid and vapour. Toxic if inhaled. Causes skin irritation. May cause cancer. Suspected of damaging fertility or the unborn child. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways.

Indicaciones de precaución: P210-P260-P301+P310a-P303+P361+P353-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF SWALLOWED: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
1902903
Clase de peligro
6.1
Grupo de embalaje
I
Código de tarifa arancelaria unificado
2931.90
TSCA
No

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