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14774-37-9 - 4-(Hydroxymethyl)tetrahydropyran, 98% - 4-Tetrahydropyranmethanol - H64568 - Alfa Aesar

H64568 4-(Hydroxymethyl)tetrahydropyran, 98%

Número CAS
14774-37-9
Nombre Alternativo
4-Tetrahydropyranmethanol

Tamaño Precio ($) Cantidad Disponibilidad
250mg 20,40
1g 52,00
5g 208,00
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4-(Hydroxymethyl)tetrahydropyran, 98%

MDL
MFCD00457804

Propiedades químicas

Fórmula
C6H12O2
Peso molecular
116.16
Punto de ebullición
111-115°/15mm
Punto de inflamabilidad
61°(142°F)
Índice de refracción
1.4600
Solubilidad
Slightly soluble in water.

Aplicaciones

Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.

Notas

Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.

Referencias documentales

Paul A. Roethle; Ryan M. McFadden; Hong Yang; Paul Hrvatin; Hon Hui; Michael Graupe; Brian Gallagher; Jessica Chao; Joseph Hesselgesser; Paul Duatschek; Jim Zheng; Bing Lu; Daniel B. Tumas; Jason Perry; and Randall L. Halcomb. Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis. J. Med. Chem.2013 56(18), 7324-7333.

Jennifer M. Frost; Michael J. Dart; Karin R. Tietje; Tiffany R. Garrison; George K. Grayson; Anthony V. Daza; Odile F. El-Kouhen; Betty B. Yao; Gin C. Hsieh; Madhavi Pai; Chang Z. Zhu; Prasant Chandran; and Michael D. Meyer. Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity. J. Med. Chem.2010 53(1), 295-315.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H318-H315-H335-H227

Causes serious eye damage. Causes skin irritation. May cause respiratory irritation. Combustible liquid.

Indicaciones de precaución: P210-P261-P280-P305+P351+P338-P304+P340-P310-P362-P312-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Beilstein
103069
Código de tarifa arancelaria unificado
2932.99
TSCA
No

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