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J60155 Okadaic acid, 98%

Número CAS
78111-17-8
Nombre Alternativo

Stock No. Tamaño Precio ($) Cantidad Disponibilidad
J60155-I& 50microgram 96,00
J60155-!G 100microg 170,00
J60155-!S 300microg 460,00
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Okadaic acid, 98%

MDL
MFCD00083455

Propiedades químicas

Fórmula
C44H68O13
Peso molecular
805.02
Formulario
Powder
Storage & Sensitivity
Store at -20°C.
Solubilidad
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Aplicaciones

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Referencias documentales

Haystead et al. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature .  1989, 337,(6202), 78-81.

Nuydens et al. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998, 70,(3), 1124-33.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H300-H310-H330-H315

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation.

Indicaciones de precaución: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,6819
Clase de peligro
6.1
Grupo de embalaje
I
Código de tarifa arancelaria unificado
2932.19
TSCA
No
RTECS
AA8227800

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