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68844-77-9 - Astemizole, 99+% - 1-(4-Fluorobenzyl)-2-(1-[4-methoxyphenethyl]piperidin-4-yl)aminobenzimidazole - Hismanal - J60339 - Alfa Aesar

J60339 Astemizole, 99+%

Número CAS
68844-77-9
Nombre Alternativo
1-(4-Fluorobenzyl)-2-(1-[4-methoxyphenethyl]piperidin-4-yl)aminobenzimidazole
Hismanal

Tamaño Precio ($) Cantidad Disponibilidad
50mg 129,00
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Astemizole, 99+%

MDL
MFCD00153919
EINECS
272-441-9

Propiedades químicas

Fórmula
C28H31FN4O
Peso molecular
458.57
Formulario
Powder
Punto de fusión
149-150°
Solubilidad
It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).

Aplicaciones

Astemizole, is used as a potent and selective H1-receptor antagonist that displays antihistamine and antimalarial activity. It is also been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C Store with desiccant. Light sensitive.

Referencias documentales

Cavalli et al. Towards a pharmacophore for drugs inducing the long QT syndrome: Insights from a CoMFA study of hERG K+ channel blockers. . J.Med.Chem.. 2002, 45,(18), 3844-53.

Chong et al. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat.Chem.Biol. 2006, 2,(8), 415-6.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,856
Código de tarifa arancelaria unificado
2933.39
TSCA
No
RTECS
DD8968000

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