Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.
Sadaji Yokoyama,; Atsuko Ogawa,; Akira Obayashi. Rapid extraction of uricase from Candida utilis cells by use of reducing agent plus surfactant. Enzyme and Microbial Technology. 1988, 10 (1), 52-55.
Chen Z,; Wang Z,; He X,; Guo X,; Li W,; Zhang B .Uricase production by a recombinant Hansenula polymorpha strain harboring Candida utilis uricase gene.. Appl Microbiol Biotechnol. 2008, 79 (4), 545-54. .