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109511-58-2 - U0126, 99+% - 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene - J61246 - Alfa Aesar

J61246 U0126, 99+%

Número CAS
109511-58-2
Nombre Alternativo
1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene

Tamaño Precio ($) Cantidad Disponibilidad
25mg 168,92
100mg 302,82
300mg 612,00
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U0126, 99+%

MDL
MFCD01861186

Propiedades químicas

Fórmula
C18H16N6S2
Peso molecular
380.49
Formulario
Powder
Solubilidad
Soluble in DMSO. Poorly soluble in ethanol and water

Aplicaciones

U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

Notas

U0126 is hygroscopic and photosensitive. Store in a tightly sealed vial and protect from light. Store at -20?C. Solid product is stable 1 year at -20°C.

Referencias documentales

Duncia et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.. Bioorg.Med.Chem.Lett. 1998, 8,(20), 2839-44.

Favata et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J.Biol.Chem. 1998, 273,(29), 18623-32.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Código de tarifa arancelaria unificado
2930.90
TSCA
No
RTECS
EJ9710000

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