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28643-80-3 - Nigericin sodium salt, 98+% - Antibiotic K178 sodium salt - J61349 - Alfa Aesar

J61349 Nigericin sodium salt, 98+%

Número CAS
28643-80-3
Nombre Alternativo
Antibiotic K178 sodium salt

Tamaño Precio ($) Cantidad Disponibilidad
10mg 140,08
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Nigericin sodium salt, 98+%

MDL
MFCD00036825

Propiedades químicas

Fórmula
C40H67NaO11
Peso molecular
746.94
Formulario
Powder
Solubilidad
Soluble in chloroform, methanol or ethanol

Aplicaciones

Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.

Notas

Stable under recommended storage conditions. Incompatible with oxidizing agents, acids, bases and heat.

Referencias documentales

K.Suzuki; K.Tohda; H.Aruga; M.Matsuzoe; H.Inoue; T.Shirai. Ion-selective electrodes based on natural carboxylic polyether antibiotics. Analytical chemistry. 1988, 60,(17), 1714-1721.

 

Benjamin Rey; Damien Roussel; Caroline Romestaing; Maud Belouze; Jean-Louis Rouanet; Dominique Desplanches; Brigitte Sibille; Stephane Servais; Claude Duchamp. Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria. BMC Physiology. 2010, 10,5.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,6541
Beilstein
3892398
Clase de peligro
6.1
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2941.90
TSCA
No
RTECS
QT6840000

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