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104594-70-9 - Phenylethyl 3,4-dihydroxycinnamate, 99+% - 3,4-Dihydroxycinnamic acid phenylethyl ester - Phenylethyl caffeate - J61386 - Alfa Aesar

J61386 Phenylethyl 3,4-dihydroxycinnamate, 99+%

Número CAS
104594-70-9
Nombre Alternativo
3,4-Dihydroxycinnamic acid phenylethyl ester
Phenylethyl caffeate

Tamaño Precio ($) Cantidad Disponibilidad
250mg 125,00
1g 372,00
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Phenylethyl 3,4-dihydroxycinnamate, 99+%

MDL
MFCD00866470

Propiedades químicas

Fórmula
C17H16O4
Peso molecular
284.31
Formulario
Crystalline powder
Punto de fusión
127-129°
Sensibilidad
Light Sensitive
Solubilidad
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.

Aplicaciones

Phenylethyl 3,4-dihydroxycinnamate is a potent and specific inhibitor of nuclear transcription factor, NF-κB, activation. It has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. It inhibits HIV-1 integrase and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Notas

Light sensitive. Incompatible with oxidizing agents and heat.

Referencias documentales

M.R.Fesen; Y.Pommier; F.Leteurtre; S.Hiroguchi; J.Yung; K.W.Kohn; Mark R.Fesen; Yves Pommier; Francois Leteurtre; Satoshi Hiroguchi; Jessie Yung; Kurt W.Kohn. Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds. Biochemical Pharmacology. 1994, 48,(3), 595-608.

 

Z.S.Zheng; G.Z.Xue; D.Grunberger; J.H.Prystowsky. Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase. Oncology Research. 1995, 7,(9), 445-452.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Código de tarifa arancelaria unificado
2918.29
TSCA
No
RTECS
UD3334375

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