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56-25-7 - Cantharidin, 98% - J61801 - Alfa Aesar

J61801 Cantharidin, 98%

Número CAS
56-25-7
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
100mg 183,00
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Cantharidin, 98%

MDL
MFCD00134968
EINECS
200-263-3

Propiedades químicas

Fórmula
C10H12O4
Peso molecular
196.20
Formulario
Powder
Punto de fusión
215-217°
Solubilidad
Soluble in DMSO (25 mg/ml warm), acetone (8 mg/ml), ethanol (8 mg/ml warm), chloroform (1:65), ether (1:560), and ethyl acetate (1:150).

Aplicaciones

Cantharidin is used as a potent inhibitor of PP2A phosphatase activity. It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.

Referencias documentales

T I Baskin; J E Wilson. Inhibitors of protein kinases and phosphatases alter root morphology and disorganize cortical microtubules. Plant Physiology.1997, 113 , (2), 493-502.

McCluskey A.; Sim A.T.R.; and Sakoff J.A. Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies. J Med Chem.2002, 45 , (6), 1151-1175.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H300-H315-H319-H335

Fatal if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,1752
Clase de peligro
6.1
Grupo de embalaje
I
Código de tarifa arancelaria unificado
2918.99
TSCA
Yes
RTECS
RN8575000

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