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11089-65-9 - Tunicamycin, 95% - J62217 - Alfa Aesar

J62217 Tunicamycin, 95%

Número CAS
11089-65-9
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
10mg 171,00
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Tunicamycin, 95%

MDL
MFCD00065709

Propiedades químicas

Fórmula
C39H64N4O16
Peso molecular
844.95
Formulario
Powder
Sensibilidad
Moisture & Light Sensitive
Solubilidad
Soluble in methanol, ethanol, DMSO, or DMF

Aplicaciones

Tunicamycin has been widely used in the study of glycoprotein synthesis in various biological systems. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C Light sensitive. Moisture sensitive.

Referencias documentales

Ding et al. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 2007, 282, (7), 4702-10.

Duriez et al. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway. J.Biol.Chem. 2008, 283, (47), 32352-60.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H300-H330-H373

Fatal if swallowed. Fatal if inhaled. May cause damage to organs through prolonged or repeated exposure.

Indicaciones de precaución: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,9819
Beilstein
6888090
Clase de peligro
6.1
Grupo de embalaje
II
Código de tarifa arancelaria unificado
2941.90
TSCA
No
RTECS
YO7980200

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