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59721-29-8 - Camostat methanesulfate, 98% - Camostat mesylate - J62362 - Alfa Aesar

J62362 Camostat methanesulfate, 98%

Número CAS
59721-29-8
Nombre Alternativo
Camostat mesylate

Tamaño Precio ($) Cantidad Disponibilidad
25mg 96,12
100mg 264,80
500mg 476,89
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Camostat methanesulfate, 98%

MDL
MFCD00941410

Propiedades químicas

Fórmula
C20H22N4O5.CH3SO3H
Peso molecular
494.52
Formulario
Powder
Punto de fusión
164-168°
Solubilidad
Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).

Aplicaciones

It is used as a protease and Trypsin inhibitor. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Referencias documentales

Horiuchi et al. Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 1990, 252(1), 320-6.

Ishikura et al. The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 2007, 80(21), 1999-2004.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H400-H315-H319-H335-H303

Very toxic to aquatic life. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May be harmful if swallowed.

Indicaciones de precaución: P261-P273-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,1728
Clase de peligro
9
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2925.29
TSCA
No
RTECS
CY1571620

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