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31884-77-2 - Meclizine dihydrochloride monohydrate - J62464 - Alfa Aesar

J62464 Meclizine dihydrochloride monohydrate

Número CAS
31884-77-2
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
1g 32,00
5g 150,00
10g 270,00
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Meclizine dihydrochloride monohydrate

MDL
MFCD00058199

Propiedades químicas

Fórmula
C25H27ClN2•2HCl•H2O
Peso molecular
481.89 (463.88anhy)
Formulario
Powder
Punto de fusión
210-213°
Solubilidad
Insoluble in water.

Aplicaciones

Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness. Product purchased here is only for use in Research and Development.

Notas

Incompatible with heat and oxidizing agents.

Referencias documentales

Foo, W. Y. B.; Tay, H. Y.; Chan, E. C. Y.; Lau, A. J. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochem. Pharmacol. 2015, 97 (3), 320-330.

Lau, A. J.; Yang, G.; Rajaraman, G.; Baucom, C. C.; Chang, T. K. H. Differential Effect of Meclizine on the Activity of Human Pregnane X Receptor and Constitutive Androstane Receptor. J. Pharmacol. Exp. Ther. 2011, 336 (3), 816-826.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H361-H302

Suspected of damaging fertility or the unborn child. Harmful if swallowed.

Indicaciones de precaución: P201-P281-P264-P270-P202-P301+P312-P308+P313-P330-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. Do not handle until all safety precautions have been read and understood. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,5777
Código de tarifa arancelaria unificado
2933.59
TSCA
Yes

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