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77-86-1 - Tris(hydroxymethyl)aminomethane, Electrophoresis Grade, 99.9% - 2-Amino-2-hydroxymethyl-1,3-propanediol - TRIS - J62569 - Alfa Aesar

J62569 Tris(hydroxymethyl)aminomethane, Electrophoresis Grade, 99.9%

Número CAS
77-86-1
Nombre Alternativo
2-Amino-2-hydroxymethyl-1,3-propanediol
TRIS

Tamaño Precio ($) Cantidad Disponibilidad
100g 38,00
500g 159,00
Añadir al carrito Añadir al presupuesto al por mayor Ver artículo

Tris(hydroxymethyl)aminomethane, Electrophoresis Grade, 99.9%

MDL
MFCD00004679
EINECS
201-064-4

Propiedades químicas

Fórmula
C4H11NO3
Peso molecular
121.14
Formulario
Crystalline powder
Punto de fusión
168-172°
Punto de ebullición
219-220°/10mm
Densidad
1.353
Sensibilidad
Hygroscopic
Solubilidad
Not miscible or difficult to mix in water. Soluble in ethylene glycol (79.1 mg/ml), methanol (26 mg/ml), anhydrous ethanol (14.6 mg/ml), 95% ethanol (22 mg/ml), DMF (14 mg/ml), acetone (2 mg/ml), ethyl acetate (0.5 mg/ml), olive oil (0.4 mg/ml), chloroform (0.05 mg/ml), and alkaline solution.

Aplicaciones

A compound widely used as a biological buffer substance in the pH range 7—9; pKa = 8.3 at 20°C; pKa = 7.82 at 37°C. It is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins. In medicine, Tris is used as alternative to sodium bicarbonate in the treatment of metabolic acidosis. Used in chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, and soluble oils), and as an absorbent for acidic gases, biological buffer, acidimetric standard, and therapeutic alkalinizing agent. Also used in buffer systems for the freezer storage of sperm, to regulate pH in the transport of live aquatic species, cell culture media, and anti-inflammatory drugs.

Notas

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Referencias documentales

Kallet RH, et al. The treatment of acidosis in acute lung injury with tris-hydroxymethyl aminomethane (THAM).Am J Respir Crit Care Med.,2000,161(1), 1149-53.

Desmarais WT, et al. The 1.20 A resolution crystal structure of the aminopeptidase from Aeromonas proteolytica complexed with tris: a tale of buffer inhibition.Structure.,2002,10(8), 1063-72.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,9772
Beilstein
741883
Código de tarifa arancelaria unificado
2922.19
TSCA
Yes
RTECS
TY2900000

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