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59-05-2 - Methotrexate - J63075 - Alfa Aesar

J63075 Methotrexate

Número CAS
59-05-2
Nombre Alternativo

Tamaño Precio ($) Cantidad Disponibilidad
100mg 112,00
1g 571,00
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Methotrexate

MDL
MFCD00150847
EINECS
200-413-8

Propiedades químicas

Fórmula
C20H22N8O5
Peso molecular
454.44
Formulario
Powder
Sensibilidad
Light Sensitive & Hygroscopic
Solubilidad
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.

Aplicaciones

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.

Notas

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light

Referencias documentales

Allegra et al. Evidence for direct inhibition of de novo protein synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J.Biol.Chem. 1987, 262, (28), 13520-6.

Cronstein, B. N. Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis. Pharmacological Reviews . 2005, 57, (2), 163-172.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H301-H315-H319-H360

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May damage fertility or the unborn child.

Indicaciones de precaución: P201-P280-P301+P310a-P305+P351+P338-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Merck
14,5985
Clase de peligro
6.1
Grupo de embalaje
III
Código de tarifa arancelaria unificado
2933.59
TSCA
Yes
RTECS
MA1225000

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