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300801-52-9 - Cdc2-Like Kinase Inhibitor, TG003 - Clk Inhibitor - TG003 - J64690 - Alfa Aesar

J64690 Cdc2-Like Kinase Inhibitor, TG003

Número CAS
300801-52-9
Nombre Alternativo
Clk Inhibitor
TG003

Tamaño Precio ($) Cantidad Disponibilidad
5mg 77,80
50mg 519,00
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Cdc2-Like Kinase Inhibitor, TG003

MDL
MFCD00624584

Propiedades químicas

Fórmula
C13H15NO2S
Peso molecular
249.33
Formulario
Solid
Sensibilidad
Light Sensitive
Solubilidad
Soluble in DMSO

Aplicaciones

Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.

Notas

Keep container tightly closed. Store in cool, dry conditions in well sealed containers. It is sensitive to light.

Referencias documentales

Yasushi Ogawa.; Yosuke Nonaka.; Toshiyasu Goto.; Eriko Ohnishi.; Toshiyuki Hiramatsu.; Isao Kii.; Miyo Yoshida.; Teikichi Ikura.; Hiroshi Onogi.; Hiroshi Shibuya.; Takamitsu Hosoya.; Nobutoshi Ito.; Masatoshi Hagiwara. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nature Communications. 2010, 1 86.

Indicaciones de peligro y de precaución del GHS

Indicaciones de peligro (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Indicaciones de precaución: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Otras referencias

Código de tarifa arancelaria unificado
2934.20
TSCA
No

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